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Can You Have Anti-Wrinkle Injections and Polynucleotides Together?

By Mary Basiadima, 6 May 2025

As aesthetic become more advanced, many people are exploring ways to combine different therapies for enhanced results. One question that often comes up is: can you have anti-wrinkle injections and polynucleotides together?

The short answer is — yes, you can, and when done correctly, combining these treatments can offer a powerful synergy for smoother, healthier, more skin. Let’s take a closer look at how they work individually and why combining them might be the best approach for your skin goals.

What Are Anti-Wrinkle Injections?

are one of the most popular non-surgical treatments for reducing fine lines and wrinkles. They work by temporarily relaxing the muscles responsible for expression lines, particularly around the forehead, eyes, and mouth.

By softening muscle activity, anti-wrinkle injections smooth out existing lines and help prevent new ones from forming. The result is a fresher, more youthful appearance, with treatments typically lasting three to four months before a top-up is needed.

What Are Polynucleotides?

are an exciting in regenerative . from highly purified Salmon DNA fragments, they work differently from or injections. Polynucleotides stimulate the skin’s natural repair processes, boosting collagen and elastin production and improving skin quality at a cellular level.

Rather than simply addressing wrinkles or volume loss, polynucleotides target skin health more broadly, improving hydration, texture, and elasticity. This makes them ideal for anyone looking for a natural, regenerative approach to skin ageing.

Can You Have Anti-Wrinkle Injections and Polynucleotides Together?

Absolutely. In fact, combining anti-wrinkle injections and polynucleotides can be a highly effective strategy for comprehensive facial rejuvenation.

Used together, these treatments tackle ageing on multiple fronts: reducing muscle activity to smooth wrinkles, while encouraging the skin to heal and regenerate naturally. The result is not only fewer lines but also healthier, firmer, and more radiant skin.

Many clients at our Clinics choose to combine these during the same visit or space them a few weeks apart, depending on individual skin needs and goals.

Are There Benefits to Combining the Two Treatments?

Yes — combining treatments can deliver enhanced, more natural-looking results compared to using either treatment alone. Some key benefits include:

By addressing both the muscles and the skin itself, you create a multi-dimensional approach to anti-ageing that’s difficult to achieve with a single treatment alone.

Is It Safe to Combine Anti-Wrinkle Injections and Polynucleotides?

Yes, when performed by an experienced practitioner, it is entirely safe to combine these treatments. At our Clinics, all procedures are out by trained professionals who assess your skin carefully and customise treatment plans to suit your individual needs.

It’s important to have a thorough consultation to determine the best timing and combination strategy for you. Sometimes, may be done during the same appointment, while in other cases, a short gap between procedures might be recommended to maximise and comfort.

How Soon Will I See Results?

injections: Typically, results become visible within 3 to 7 days, with full effects at around two weeks.

Polynucleotides: Improvements in skin quality develop gradually over several weeks, as collagen and elastin production increase.

When combined, you can expect to see both immediate improvements in wrinkles and gradual in skin texture and firmness over time, offering a refreshed, youthful appearance that continues to improve.

Combining Treatments for Optimal Skin Health

So, can you have anti-wrinkle injections and polynucleotides together? The answer is yes, and the combination can deliver powerful, natural-looking rejuvenation. By targeting both muscle movement and skin health, you achieve smoother, firmer, and more radiant skin that lasts.

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The best order often depends on your individual skin goals and what you’re hoping to achieve. In many cases, anti-wrinkle injections are first to soften dynamic lines caused by muscle movement. Polynucleotides can then be introduced to improve overall skin quality, boosting hydration, firmness, and collagen production. However, some practitioners may recommend starting with polynucleotides to prepare and strengthen the skin before relaxing the muscles. Our practitioners will assess your skin during consultation and develop a treatment plan tailored to your needs for optimal results.

After receiving injections, it’s best to avoid using strong or irritating skincare for at least 24 to 48 hours. This includes exfoliants, retinol, alpha hydroxy acids (AHAs), beta hydroxy acids (BHAs), and containing alcohol. These can increase sensitivity and irritation at the injection sites. Instead, stick to gentle, hydrating skincare and always follow your practitioner’s aftercare instructions to ensure the best possible outcome.

After a polynucleotide treatment, it’s important to avoid certain to allow your skin to heal and maximise results. For at least 24 to 48 hours, avoid exercise, hot baths or saunas, and makeup over the treated area. You should also stay out of direct sunlight and always use a broad-spectrum SPF if you need to go outside. Gentle skincare is recommended, and it’s best to avoid exfoliants, active ingredients, or harsh treatments until your practitioner advises it’s safe. Proper aftercare helps ensure your skin benefits fully from the regenerative effects of polynucleotides.

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